Where Design Defines the Experience
This is the heart of DNA Hotels. A design-led hotel doesn’t have to be created by a famous architect or interior designer—it can be carefully designed from the ground up or have evolved organically over decades. What matters is that everything feels connected: architecture, interiors, furniture, materials, light and atmosphere. These are hotels with a clear point of view, where design isn’t decoration or a marketing label, but part of the character of the place and the way you experience it.
Aenaon Villas | Imerovigli, Santorini | Greece An Intimate Cliffside Retreat Where Cycladic Simplicity Meets Endless Horizon Why DNA Hotels Loves It ● Seven beautifully crafted villas perched on Santorini's highest and narrowest point, offering uninterrupted views from sunrise to sunset. ● Authentic Cycladic architecture designed by Giorgos Zacharopoulos in close collaboration with owners Giorgos…
read moreSanto Pure Oia Suites & Villas | Santorini, Greece A Village-Style Retreat Where Cycladic Architecture Meets Quiet Luxury Why DNA Hotels Loves It ● A beautifully conceived adults-only retreat designed as a contemporary Cycladic village just moments from Oia. ● Spacious suites and villas centred around five infinity pools, combining understated design with exceptional privacy.…
read moreWhite Ark | Thira, Santorini | Greece A Three-Villa Cliffside Retreat Where Minimalism Frames the Caldera Why DNA Hotels Loves It ● An exceptionally intimate hideaway with just three private cave villas overlooking Santorini's spectacular caldera. ● Sensitive restoration by architects Alexandros and Marianna Kapsimalis, celebrating traditional cave architecture through restrained contemporary design. ● Private…
read moreOlea All Suite Hotel | Zakynthos, Greece A Tropical-Modernist Retreat Where Water Shapes the Architecture Why DNA Hotels Loves It ● A striking hillside resort by Block722architects+, conceived as a fluid landscape of water, gardens, and tropical-modernist architecture. ● Ninety-three spacious suites arranged around a 4,000-square-metre lagoon pool, many with direct water access or private…
read moreYours Truly DC | Washington, D.C., USA Brutalist Bones, Bohemian Soul Why DNA Hotels Loves It ● A striking reinvention of a 1971 Brutalist landmark that transforms concrete architecture into one of Washington's most creative hospitality spaces. ● A vibrant living-room concept where locals and travelers naturally mingle over coffee by day and cocktails by…
read moreSan Luis Creek Lodge | San Luis Obispo, California | USA Scandinavian Simplicity Meets California's Central Coast Why DNA Hotels Loves It ● A beautifully reimagined roadside lodge where Nina Freudenberger combines Scandinavian restraint with relaxed California living. ● Thoughtfully designed guestrooms featuring natural materials, handcrafted details, and three distinctive colour palettes inspired by the…
read moreAlila Napa Valley - St. Helena, California, USA Where vineyard views, quiet modernism, and wine-country heritage settle into a slower rhythm. Why DNA Hotels Loves It ● The former Las Alcobas has been reimagined as an Alila retreat without losing the Yabu Pushelberg interiors that made the original property such a strong piece of contemporary…
read moreThe Pearl Hotel | San Diego, California | USA Mid-Century California Reimagined Why DNA Hotels Loves It ● A beautifully restored 1960s motor lodge that celebrates authentic mid-century California design with a fresh contemporary twist. ● The iconic oyster-shaped pool, preserved neon sign, and retro architectural details give the hotel a personality few boutique properties…
read moreThe Guild Hotel | San Diego, California | USA Historic Grandeur Reimagined for Modern San Diego Why DNA Hotels Loves It ● A beautifully restored 1924 Italianate Renaissance landmark that transforms one of San Diego's most historic buildings into a sophisticated boutique hotel. ● Exceptional adaptive reuse, where former basketball courts, running tracks, and even…
read moreSkyview Los Alamos - California, USA Where a 1950s roadside motel gets a second life among the vineyards of Santa Ynez Valley. Why DNA Hotels Loves It ● A late-1950s motor lodge rescued from abandonment and reinvented without erasing its mid-century California and Western roots. ● Original motel details — from the kidney-shaped pool and…
read moreHotel Joaquin | Laguna Beach, California | USA From Roadside Motel to Design-Forward Escape Why DNA Hotels Loves It ● A beautifully reimagined 1940s roadside motel that captures the spirit of Southern California's mid-century beach culture through timeless, residential design. ● Interiors by Studio Robert McKinley blend vintage furniture, handcrafted materials, curated local art, and…
read moreHarmon Guest House - Healdsburg, California, USA Modern California architecture, local craft and serious sustainability in the heart of Sonoma wine country. Why DNA Hotels Loves It ● David Baker Architects created a genuinely Californian hotel rather than borrowing from the Tuscan and Provençal architecture so often associated with wine-country hospitality. ● Sustainability is part…
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