Where Design Defines the Experience
This is the heart of DNA Hotels. A design-led hotel doesn’t have to be created by a famous architect or interior designer—it can be carefully designed from the ground up or have evolved organically over decades. What matters is that everything feels connected: architecture, interiors, furniture, materials, light and atmosphere. These are hotels with a clear point of view, where design isn’t decoration or a marketing label, but part of the character of the place and the way you experience it.
The Box – Riccione, Italy A once-abandoned Adriatic Riviera hotel reinvented with global design, playful details and a distinctly contemporary attitude. Why DNA Hotels Loves It ● Architects Marianna Chiaraluce and Alfredo Monetti transformed the abandoned Hotel Sixty into something Riccione didn't have: a genuinely design-driven boutique hotel. ● Its interiors bring together an unusually…
read moreParagon 700 Boutique Hotel & Spa – Ostuni, Puglia, Italy An 18th-century red palazzo that breaks every rule of the White City with eclectic interiors, secret gardens and a rebellious sense of glamour. Why DNA Hotels Loves It ● Ostuni’s unmistakable Pompeian-red Palazzo Rosso, restored by owners and designers Pascale Lauber and Ulrike Bauschke as…
read moreVilla Arnica | Lana, South Tyrol | Italy A 1920s Garden Villa Where Vintage Elegance Meets the Ease of Modern South Tyrol Why DNA Hotels Loves It ● A beautifully restored 1925 villa where original architecture, antique finds, and Italian mid-century design create a richly layered sense of place. ● Just ten adults-only rooms and…
read moreSchgaguler Hotel | Kastelruth (Castelrotto), South Tyrol | Italy A Contemporary Alpine Landmark Where Peter Pichler Reimagines the Mountain Hotel Why DNA Hotels Loves It ● A remarkable transformation by Peter Pichler Architecture, replacing Alpine nostalgia with sculptural contemporary design while remaining deeply connected to the Dolomites. ● Beautifully restrained interiors where bespoke chestnut joinery,…
read moreDas Wanda | Kaltern (Caldaro), South Tyrol | Italy An Adults-Only Retreat Where Contemporary Design Meets the Gentle Rhythm of South Tyrol Why DNA Hotels Loves It ● A beautifully restored villa where contemporary architecture, natural materials, and South Tyrolean craftsmanship create an atmosphere of quiet sophistication. ● Just twelve individually designed suites and studios…
read moreThe Social Hub Florence Lavagnini | Italy Where a historic Florentine palazzo has been transformed into one of Europe's most vibrant design-led communities for travelers, creatives, students, and entrepreneurs. Why DNA Hotels Loves It ● A beautifully restored historic landmark that combines Renaissance architecture with bold contemporary interiors. ● An innovative hospitality concept where hotel,…
read moreVelona's Jungle Luxury Suites | Florence, Italy An Eclectic Family Residence Where Mid-Century Design Meets Florentine Hospitality Why DNA Hotels Loves It ● A deeply personal ten-suite retreat created inside the former home of one of Florence's most respected antique dealers. ● Eclectic interiors layered with mid-century furniture, vintage treasures, bold textiles, and nature-inspired design.…
read moreOltrarno Splendid | Florence, Italy An Eclectic Florentine Guesthouse Where Renaissance Heritage Meets Contemporary Creativity Why DNA Hotels Loves It ● A beautifully restored 16th-century palazzo brought to life by the visionary team behind AdAstra and SoprArno Suites. ● Fourteen individually designed rooms where frescoes, antique details, mid-century icons, and contemporary design coexist effortlessly. ●…
read moreAdAstra Suites | Florence, Italy A Bohemian Palazzo Where Aristocratic Florence Meets Mid-Century Design Why DNA Hotels Loves It ● A remarkable nine-room retreat inside a historic Florentine palazzo overlooking Europe's largest private urban garden, the Giardino Torrigiani. ● Eclectic interiors combining frescoed ceilings, original parquet, Italian mid-century design, antiques, and contemporary classics. ● One…
read moreNumeroventi Design Residency | Florence, Italy Where Renaissance Heritage Becomes a Living Creative Community Why DNA Hotels Loves It ● A beautifully restored 16th-century Florentine palazzo that combines boutique accommodation with an internationally respected artist residency. ● Minimalist interiors by Andrew Trotter blend Renaissance architecture with Scandinavian restraint, creating one of Florence's most serene design…
read moreVIVERE suites and rooms | Arco, Italy A Contemporary Agriturismo Where Modern Architecture Embraces the Landscape Why DNA Hotels Loves It ● A striking modernist retreat by Genuizzi | Banal Architetti that redefines the traditional Italian agriturismo. ● Just six beautifully designed suites immersed in vineyards, olive groves, and the dramatic landscapes of Trentino. ●…
read moreSolar de Vila Meã – Vila Meã, PortugalWhere Craftsmanship, Heritage, and Contemporary Design Flow Together Why DNA Hotels Loves It ● A beautifully restored 19th-century manor that celebrates Portuguese craftsmanship through every material, detail, and space. ● Distinctive interiors where terracotta, wickerwork, embroidery, and local artistry create a strong sense of place. ● A sophisticated…
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